2024

  1. COMBINATORIAL DESIGN OF SILOXANE-INCORPORATED LIPID NANOPARTICLES AUGMENTS INTRACELLULAR PROCESSING FOR TISSUE-SPECIFIC mRNA THERAPEUTIC DELIVERY
    L. Xue, G. Zhao, N. Gong, X. Han, S.J. Shepherd, X. Xiong, Z. Xiao, R. Palanki, J. Xu, K.L. Swingle, C.C. Warzecha, R. El-Mayta, V. Chowdhary, I.C. Yoon, J. Xu, J. Cui, Y. Shi, M.G. Alameh, K. Wang, L. Wang, D.J. Pochan, D. Weissman, A.E. Vaughan, J.M. Wilson, M.J. Mitchell
    Nature Nanotechnology (2024) PDF
  1. SMALL STRUCTURAL CHANGES IN SILOXANE-BASED LIPIDOIDS IMPROVE TISSUE-SPECIFIC mRNA DELIVERY
    L. Xue, K.L. Swingle, M.J. Mitchell
    Nature Nanotechnology (2024) PDF
  1. LIPID NANOPARTICLE-MEDIATED RNA DELIVERY FOR IMMUNE CELL MODULATION
    E.H. Kim, S.V. Teerdhala, M.S. Padilla, R.A. Joseph, J.J. Li, R.M. Haley, M.J. Mitchell
    European Journal of Immunology (2024) PDF
  1. TUMOUR-DERIVED SMALL EXTRACELLULAR VESICLES ACT AS A BARRIER TO THERAPEUTIC NANOPARTICLE DELIVERY
    N. Gong, W. Zhong, M.G. Alameh, X. Han, L. Xue, R. El-Mayta, G. Zhao, A.E. Vaughan, Z. Qin, F. Xu, A.G. Hamilton, D. Kim, J. Xu, J. Kim, X. Teng, J. Li, X.J. Liang, D. Weissman, W. Guo, M.J. Mitchell
    Nature Materials (2024) PDF
  1. FINE-TUNING EXTRACELLULAR FLUID VISCOSITY ENHANCES GENE DELIVERY
    A.S. Thatte, D. Kim, M.J. Mitchell
    Nature Chemical Engineering (2024) PDF
  1. IN UTERO DELIVERY OF TARGETED IONIZABLE LIPID NANOPARTICLES FACILITATES IN VIVO GENE EDITING OF HEMATOPOIETIC STEM CELLS
    R. Palanki, J.S. Riley, S.K. Bose, V. Luks, A. Dave, N. Kus, B.M. White, A.S. Ricciardi, K.L. Swingle, L. Xue, D. Sung, A.S. Thatte, H.C. Safford, V.S. Chaluvadi, M. Carpenter, E.L. Han, R. Maganti, A.G. Hamilton, K. Mrksich, M. Billingsley, P.W. Zoltick, M.G. Alameh, D. Weissman, M.J. Mitchell, W.H. Peranteau
    PNAS (2024) PDF
  1. DRUG DELIVERY TECHNOLOGIES FOR AUTOIMMUNITY THERAPIES
    A.S. Thatte, J.D. Weaver, R. Pearson, M.J. Mitchell
    Advanced Drug Delivery Reviews (2024) PDF
  1. OPTIMIZED MICROFLUIDIC FORMULATION AND ORGANIC EXCIPIENTS FOR IMPROVED LIPID NANOPARTICLE MEDIATED GENOME EDITING
    R. Palanki, E.L. Han, A.M. Murray, R. Maganti, S. Tang, K.L. Swingle, D. Kim, H. Yamagata, H.C. Safford, K. Mrksich, W.H. Peranteau, M.J. Mitchell
    Lab on a Chip (2024) PDF
  1. FAST AND FACILE SYNTHESIS OF AMIDINE-INCORPORATED DEGRADABLE LIPIDS FOR VERSATILE mRNA DELIVERY IN VIVO 
    X. Han, M.G. Alameh, N. Gong, L. Xue, M. Ghattas, G. Boija, J. Xu, G. Zhao, C.C. Warzecha, M.S. Padilla, R. El-Mayta, G. Dwivedi, Y. Xu, A.E. Vaughan, J.M. Wilson, D. Weissman, M.J. Mitchell
    Nature Chemistry (2024) PDF
  1. LIPID-MEDIATED INTRACELLULAR DELIVERY OF RECOMBINANT bioPROTACs FOR THE RAPID DEGRADATION OF UNDRUGGABLE TARGETS 
    A. Chan, R.M. Haley, M.A. Najar, D. Gonzalez-Martinez, L. Bugaj, G.M. Burslem, M.J. Mitchell, A. Tsourkas
    Nature Communications (2024) PDF
  1. ENHANCING IN SITU VACCINES USING DELIVERY TECHNOLOGIES 
    N. Gong, M.G. Alameh, R. El-Mayta, L. Xue, D. Weissman, M.J. Mitchell
    Nature Reviews Drug Discovery (2024) PDF
  1. HIGH-THROUGHPUT IN VIVO SCREENING IDENTIFIES DIFFERENTIAL INFLUENCES ON mRNA LIPID NANOPARTICLE IMMUNE CELL DELIVERY BY ADMINISTRATION ROUTE 
    A.G. Hamilton, K.L. Swingle, A.S. Thatte, A.J. Mukalel, H.C. Safford, M.M. Billingsley, R. El-Mayta, X. Han, B.E. Nachod, R.A. Joseph, A.E. Metzloff, M.J. Mitchell
    ACS Nano (2024) PDF
  1. EGFR-TARGETED IONIZABLE LIPID NANOPARTICLES ENHANCE IN VIVO mRNA DELIVERY TO THE PLACENTA
    H.C. Geisler, A.A. Ghalsasi, H.C. Safford, K.L. Swingle, A.S. Thatte, A.J. Mukalel, N. Gong, A.G. Hamilton, E.L. Han, B.E. Nachod, M.S. Padilla, M.J. Mitchell
    Journal of Controlled Release (2024) PDF
  1. MECHANISMS AND BARRIERS IN NANOMEDICINE: PROGRESS IN THE FIELD AND FUTURE DIRECTIONS
    T. Anchordoquy, N. Artzi, I.V. Balyasnikova, Y. Barenholz, N.M. La-Beck, J.S. Brenner, W.C.W. Chan, P. Decuzzi, A.A. Exner, A. Gabizon, B. Godin, S.K. Lai, T. Lammers, M.J. Mitchell, S.M. Moghimi, V.R. Muzykantov, D. Peer, J. Nguyen, R. Popovtzer, M. Ricco, N.J. Serkova, R. Singh, A. Schroeder, A.A. Schwendeman, J.P. Straehla, T. Teesalu, S. Tilden, D. Simberg
    ACS Nano (2024) PDF
  1. VASCULAR ENDOTHELIAL-DERIVED SPARCL1 EXACERBATES VIRAL PNEUMONIA THROUGH PRO-INFLAMMATORY MACROPHAGE ACTIVATION
    G. Zhao, M.E. Gentile, L. Xue, C.V. Cosgriff, A.I. Weiner, S. Adams-Tzivelekidis, J. Wong, X. Li, S. Kass-Gergi, N.P. Holcomb, M.C. Basal, K.M. Stewart, J.D. Planer, E. Cantu, J.D. Christie, M.M. Crespo, M.J. Mitchell, N.J. Meyer, A.E. Vaughan
    Nature Communications (2024) PDF
  1. IONIZABLE LIPID NANOPARTICLES FOR RAS PROTEASE DELIVERY TO INHIBIT CANCER CELL PROLIFERATION
    E. Atsavapranee, R.M. Haley, M.M. Billingsley, A. Chan, B. Ruan, C.G. Figueroa-Espada, N. Gong, A.J. Mukalel, P.N. Bryan, M.J. Mitchell
    Journal of Controlled Release (2024) PDF
  1. ANTIGEN PRESENTING CELL MIMETIC LIPID NANOPARTICLES FOR RAPID mRNA CAR T CELL CANCER IMMUNOTHERAPY
    A.E. Metzloff, M.S. Padilla, N. Gong, M.M. Billingsley, X. Han, M. Merolle, D. Mai, C.G. Figueroa-Espada, A.S. Thatte, R.M. Haley, A.J. Mukalel, A.G. Hamilton, M.G. Alameh, D. Weissman, N.C. Sheppard, C.H. June, M.J. Mitchell
    Advanced Materials (2024) PDF
  1. INFLUENCE OF IONIZABLE LIPID TAIL LENGTH ON LIPID NANOPARTICLE DELIVERY OF mRNA OF VARYING LENGTH
    K. Mrksich, M.S. Padilla, R.A. Joseph, E.L. Han, D. Kim, R. Palanki, J. Xu, M.J. Mitchell
    Journal of Biomedical Materials Research Part A (2024) PDF
  1. IONIZABLE LIPID NANOPARTICLE-MEDIATED TRAIL mRNA DELIVERY IN THE TUMOR MICROENVIRONMENT TO INHIBIT COLON CANCER PROGRESSION
    W.N. Silva, P.A.C. Costa, S.R.A. Scalzo, H.A.S. Ferreira, P.H.D.M. Prazeres, C.L.V. Campos, M.T. Rodrigues Alves, N.J. Alves da Silva, A.L. de Castro Santos, L.C. Guimaraes, M.E.C. Ferris, A.S. Thatte, A.G. Hamilton, K.A. Bicalho, A.O. Lobo, H.D.C. Santiago, L. da Silva Barcelos, M.M. Figueredo, M.M. Teixeira, C. Vasconcelos Costa, M.J. Mitchell, F. Frezard, P.P.G. Guimaraes
    International Journal of Nanomedicine (2024) PDF
  1. OXIDIZED mRNA LIPID NANOPARTICLES FOR IN SITU CHIMERIC ANTIGEN RECEPTOR MONOCYTE ENGINEERING
    A.J. Mukalel, A.G. Hamilton, M.M. Billingsley, J. Li, A.S. Thatte, X. Han, H.C. Safford, M.S. Padilla, T. Papp, H. Parhiz, D. Weissman, M.J. Mitchell
    Advanced Functional Materials (2024) PDF
  1. HIGH-THROUGHPUT BARCODING OF NANOPARTICLES IDENTIFIES CATIONIC, DEGRADABLE LIPID-LIKE MATERIALS FOR mRNA DELIVERY TO THE LUNGS IN FEMALE PRECLINICAL MODELS
    L. Xue, A.G. Hamilton, G. Zhao, Z. Xiao, R. El-Mayta, X. Han, N. Gong, X. Xiong, J. Xu, C.G. Figueroa-Espada, S.J. Shepherd, A.J. Mukalel, M.G. Alameh, J. Cui, K. Wang, A.E. Vaughan, D. Weissman, M.J. Mitchell
    Nature Communications (2024) PDF
  1. IN SITU COMBINATORIAL SYNTHESIS OF DEGRADABLE BRANCHED LIPIDOIDS FOR SYSTEMIC DELIVERY OF mRNA THERAPEUTICS AND GENE EDITORS
    X. Han, J. Xu, Y. Xu, M.G. Alameh, L. Xue, N. Gong, R. El-Mayta, R. Palanki, C.C. Warzecha, G. Zhao, A.E. Vaughan, J.M. Wilson, D. Weissman, M.J. Mitchell
    Nature Communications (2024) PDF
  1. SMALL-MOLECULE-MEDIATED CONTROL OF THE ANTI-TUMOUR ACTIVITY AND OFF-TUMOUR TOXICITY OF A SUPRAMOLECULAR BISPECIFIC T CELL ENGAGER
    N. Gong, X. Han, L. Xue, M.M. Billingsley, X. Huang, R. El-Mayta, J. Qin, N.C. Sheppard, C.H. June, M.J. Mitchell
    Nature Biomedical Engineering (2024) PDF
  1. EMERGING STRATEGIES FOR NANOMEDICINE IN AUTOIMMUNITY
    A.S. Thatte, M.M. Billingsley, D. Weissman, J.R. Melamed, M.J. Mitchell
    Advanced Drug Delivery Reviews (2024) PDF
  1. AN IMMUNOSUPPRESSIVE VASCULAR NICHE DRIVES MACROPHAGE POLARIZATION AND IMMUNOTHERAPY RESISTANCE IN GLIOBLASTOMA
    F. Yang, M.N. Akhtar, D. Zhang, R. El-Mayta, J. Shin, J.F. Dorsey, L. Zhang, X. Xu, W. Guo, S.J. Bagley, S.Y. Fuchs, C. Koumenis, J.D. Lathia, M.J. Mitchell, Y. Gong, Y. Fan
    Science Advances (2024) PDF
  1. PRECISION TREATMENT OF VIRAL PNEUMONIA THROUGH MACROPHAGE-TARGETED LIPID NANOPARTICLE DELIVERY
    G. Zhao, L. Xue, H.C. Geisler, J. Xu, X. Li, M.J. Mitchell, A.E. Vaughan
    PNAS (2024) PDF
  1. TGF-βR2 SIGNALING COORDINATES PULMONARY VASCULAR REPAIR AFTER VIRAL INJURY IN MICE AND HUMAN TISSUE
    G. Zhao, L. Xue, A.I. Weiner, N. Gong, S. Adams-Tzivelekidis, J. Wong, M.E. Gentile, A.N. Nottingham, M.C. Basil, S.M. Lin, T.K. Niethamer, J.M. Diamond, C.A. Bermudez, E. Cantu, X. Han, Y. Cao, M.G. Alameh, D. Weissman, E.E. Morrisey, M.J. Mitchell, A.E. Vaughan
    Science Translational Medicine (2024) PDF
  1. MICROFLUIDIC GENERATION OF DIVERSE LIPID NANOPARTICLE LIBRARIES
    A. Hanna, S.J. Shepherd, D. Issadore, M.J. Mitchell
    Nanomedicine (2024) PDF
  1. PREDICTIVE HIGH-THROUGHPUT PLATFORM FOR DUAL SCREENING OF mRNA LIPID NANOPARTICLE BLOOD-BRAIN BARRIER TRANSFECTION AND CROSSING
    E.L. Han, M.S. Padilla, R. Palanki, D. Kim, K. Mrksich, J.J. Li, S. Tang, I.C. Yoon, M.J. Mitchell
    Nano Letters (2024) PDF
  1. NANOPARTICLE-BASED DNA VACCINE PROTECTS AGAINST SARS-CoV-2 VARIANTS IN FEMALE PRECLINICAL MODELS
    L.C. Guimaraes, P.A.C. Costa, S.R.A. Scalzo Junior, H.A.S. Ferreira, A.C.S. Braga, L.C. de Oliveira, M.M. Figueiredo, S.J. Shepherd, A.G. Hamilton, C.M. Queiroz-Junior, W.N. da Silva, N.J.A. da Silva, M.T.R. Alves, A.K. Santos, K.K.S. da Faria, F.M. Marim, H. Fukumasu, A. Birbair, A. Teixeira-Carvalho, R.S. de Aguiar, M.J. Mitchell, M.M. Teixeira, V.V. Costa, F. Frezard, P.P.G. Guimaraes
    Nature Communications (2024) PDF
  1. RESPONSIVE BIOMATERIALS: OPTIMIZING CONTROL OF CANCER IMMUNOTHERAPY
    L. Xue, A.S. Thatte, D. Mai, R.M. Haley, N. Gong, X. Han, K. Wang, N.C. Sheppard, C.H. June, M.J. Mitchell
    Nature Reviews Materials (2024) PDF
  1. AN ONCOLYTIC CIRCULAR RNA THERAPY
    A.G. Hamilton, M.J. Mitchell
    Nature Cancer (2024) PDF
  1. siRNA LIPID NANOPARTICLES FOR CXCL12 SILENCING MODULATE BRAIN IMMUNE RESPONSE DURING ZIKA INFECTION
    P.A.C. Costa, W.N. da Silva, P.H.D.M. Prazeres, H.A.S. Ferreira, N.J.A. da Silva, M.M. Figueiredo, B. Oliveira, S.R.A. Scalzo, F.R. Santos, R.A. Fernandes, R. Palanki, A.G. Hamilton, A. Birbair, V.R. Santos, A.S. de Miranda, M.J. Mitchell, M.M. Teixeira, V.V. Costa, P.P.G. Guimaraes
    Biomedicine & Pharmacotherapy (2024) PDF
  1. BILE ACID-CONTAINING LIPID NANOPARTICLES ENHANCE EXTRAHEPATIC mRNA DELIVERY
    S.K. Patel, M.M. Billingsley, A.J. Mukalel, A.S. Thatte, A.G. Hamilton, N. Gong, R. El-Mayta, H.C. Safford, M. Merolle, M.J. Mitchell
    Theranostics (2024) PDF
  1. IN VIVO mRNA CAR T CELL ENGINEERING VIA TARGETED LIPID NANOPARTICLES WITH EXTRAHEPATIC TROPISM
    M.M. Billingsley, N. Gong, A.J. Mukalel, A.S. Thatte, R. El-Mayta, S.K. Patel, A.E. Metzloff, K.L. Swingle, X. Han, L. Xue, A.G. Hamilton, H.C. Safford, M.G. Alameh, T.E. Papp, H. Parhiz, D. Weissman, M.J. Mitchell
    Small (2023) PDF
  1. ORTHOGONAL DESIGN OF EXPERIMENTS FOR ENGINEERING OF LIPID NANOPARTICLES FOR mRNA DELIVERY TO THE PLACENTA
    H.C. Safford, K.L. Swingle, H.C. Geisler, A.G. Hamilton, A.S. Thatte, A.A. Ghalsasi, M.M. Billingsley, M.G. Alameh, D. Weissman, M.J. Mitchell
    Small (2023) PDF

2023

  1. IN SITU PEGYLATION OF CAR T CELLS ALLEVIATES CYTOKINE RELEASE SYNDROME AND NEUROTOXICITY
    N. Gong, X. Han, L. Xue, R. El-Mayta, A.E. Metzloff, M.M. Billingsley, A.G. Hamilton, M.J. Mitchell
    Nature Materials (2023) PDF
  1. ADJUVANT LIPIDOID-SUBSTITUTED LIPID NANOPARTICLES AUGMENT THE IMMUNOGENICITY OF SAR-CoV-2 mRNA VACCINES
    X. Han, M.G. Alameh, K. Butowska, J.J. Knox, K. Lundgreen, M. Ghattas, N. Gong, L. Xue, Y. Xu, M. Lavertu, P. Bates, J. Xu, G. Nie, Y. Zhong, D. Weissman, M.J. Mitchell
    Nature Nanotechnology (2023) PDF
  1. mRNA LIPID NANOPARTICLES FOR EX VIVO ENGINEERING OF IMMUNOSUPPRESSIVE T CELLS FOR AUTOIMMUNITY THERAPIES
    A.S. Thatte, A.G. Hamilton, B.E. Nachod, A.J. Mukalel, M.M. Billingsley, R. Palanki, K.L. Swingle, M.J. Mitchell
    Nano Letters (2023) PDF
  1. THROUGHPUT-SCALABLE MANUFACTURING OF SARS-CoV-2 mRNA LIPID NANOPARTICLE VACCINES
    S.J. Shepherd, X. Han, A.J. Mukalel, R. El-Mayta, A.S. Thatte, J. Wu, M.S. Padilla, M.G. Alameh, N. Srikumar, D. Lee, D. Weissman, D. Issadore, M.J. Mitchell
    PNAS (2023) PDF
  1. IN VIVO BONE MARROW MICROENVIRONMENT siRNA DELIVERY USING LIPID-POLYMER NANOPARTICLES FOR MULTIPLE MYELOMA THERAPY
    P.P.G. Guimaraes, C.G. Figueroa-Espada, R.S. Riley, N. Gong, L. Xue, T. Sewastianik, P.S. Dennis, C. Loebel, A. Chung, S.J. Shepherd, R.M. Haley, A.G. Hamilton, R. El-Mayta, K. Wang, R. Langer, D.G. Anderson, R.D. Carrasco, M.J. Mitchell
    PNAS (2023) PDF
  1. IONIZABLE LIPID NANOPARTICLES WITH INTEGRATED IMMUNE CHECKPOINT INHIBITION FOR mRNA CAR T CELL ENGINEERING
    A.G. Hamilton, K.L. Swingle, R.A. Joseph, D. Mai, N. Gong, M.M. Billingsley, M.G. Alameh, D. Weissman, N.C. Sheppard, C.H. June, M.J. Mitchell
    Advanced Healthcare Materials (2023) PDF
  1. DELIVERY OF PLASMID DNA BY IONIZABLE LIPID NANOPARTICLES TO INDUCE CAR EXPRESSION IN T CELLS
    P.H.D.M. Prazeres, H. Ferreira, P.A.C. Costa, W. da Silva, M.T. Alves, M.S. Padilla, A.S. Thatte, A.K. Santos, A.O. Lobo, A. Sabino, A. Sabino, H.L. Del Puerto, M.J. Mitchell, P.P.G. Guimaraes
    International Journal of Nanomedicine (2023) PDF
  1. UPREGULATION OF EXOSOME SECRETION FROM TUMOR-ASSOCIATED MACROPHAGES PLAYS A KEY ROLE IN THE SUPPRESSION OF ANTI-TUMOR IMMUNITY
    W. Zhong, Y. Lu, X. Han, J. Yang, Z. Qin, W. Zhang, Z. Yu, B. Wu, S. Liu, W. Xu, C. Zheng, L.M. Schuchter, G.C. Karakousis, T.C. Mitchell, R. Amaravadi, A.J. Flowers, P.A. Gimotty, M. Xiao, G. Mills, M. Herlyn, H. Dong, M.J. Mitchell, J. Kim, X. Xu, W. Guo
    Cell Reports (2023) PDF
  1. siRNA LIPID-POLYMER NANOPARTICLES TARGETING E-SELECTIN AND CYCLOPHILIN A IN BONE MARROW FOR COMBINATION MULTIPLE MYELOMA THERAPY
    C.G. Figueroa-Espada, P.P.G. Guimaraes, R.S. Riley, L. Xue, K. Wang, M.J. Mitchell
    Cellular and Molecular Bioengineering (2023) PDF
  1. IONIZABLE LIPID NANOPARTICLES FOR THERAPEUTIC BASE EDITING OF CONGENITAL BRAIN DISEASE
    R. Palanki, S.K. Bose, A. Dave, B.M. White, C. Berkowitz, V. Luks, F. Yaqoob, E. Han, K.L. Swingle, P. Menon, E. Hodgson, A. Biswas, M.M. Billingsley, L. Li, F. Yiping, M. Carpenter, A. Trokhan, J. Yeo, N. Johana, T.Y. Wan, M.G. Alameh, F.C. Bennett, P.B. Storm, R. Jain, J. Chan, D. Weissman, M.J. Mitchell, W.H. Peranteau
    ACS Nano (2023) PDF
  1. TARGETED NANOCARRIERS CO-OPTING PULMONARY INTRAVASCULAR LEUKOCYTES FOR DRUG DELIVERY TO THE INJURED BRAIN
    J. Nong, P.M. Glassman, J.W. Myerson, V. Zuluaga-Ramirez, A. Rodriguez-Garcia, A.J. Mukalel, S. Omo-Lamai, L.R. Walsh, M.E. Zamora, X. Gong, Z. Wang, K. Bhamidipati, R.Y. Kiseleva, C.H. Villa, C.F. Greineder, S.E. Kasner, D. Weissman, M.J. Mitchell, S. Muro, Y. Peridsky, J.S. Brenner, V.R. Muzykantov, O.A. Marcos-Contreras
    ACS Nano (2023) PDF
  1. LIPID NANOPARTICLE DELIVERY OF SMALL PROTEINS FOR POTENT IN VIVO RAS INHIBITION
    R.M. Haley, A. Chan, M.M. Billingsley, N. Gong, M.S. Padilla, E.H. Kim, H. Wang, D. Yin, K.J. Wangensteen, A. Tsourkas, M.J. Mitchell
    ACS Applied Materials & Interfaces (2023) PDF
  1. REROUTING NANOPARTICLES TO BONE MARROW VIA NEUTROPHIL HITCHHIKING
    N. Gong, M.J. Mitchell
    Nature Nanotechnology (2023) PDF
  1. OVERCOMING BIOLOGICAL BARRIERS TO NUCLEIC ACID DELIVERY USING LIPID NANOPARTICLES
    A.G. Hamilton, K.L. Swingle, M.J. Mitchell
    PLOS Biology (2023) PDF
  1. EXOSOME-DISRUPTING PEPTIDES FOR CANCER IMMUNOTHERAPY
    N. Gong, A.G. Hamilton, M.J. Mitchell
    Nature Materials (2023) PDF
  1. A HYDROGEL-ENTRAPPED LIVE VIRUS IMMUNIZATION
    N. Gong, A.G. Hamilton, M.J. Mitchell
    Nature Biomedical Engineering (2023) PDF
  1. DELIVERY TECHNOLOGIES FOR WOMEN'S HEALTH APPLICATIONS
    K.L. Swingle, A.S. Ricciardi, W.H. Peranteau, M.J. Mitchell
    Nature Reviews Bioengineering (2023) PDF
  1. IONIZABLE LIPID NANOPARTICLES FOR IN VIVO mRNA DELIVERY TO THE PLACENTA DURING PREGNANCY
    K.L. Swingle, H.C. Safford, H.C. Geisler, A.G. Hamilton, A.S. Thatte, M.M. Billingsley, R.A. Joseph, K. Mrksich, M.S. Padilla, A.A. Ghalsasi, M.G. Alameh, D. Weissman, M.J. Mitchell
    Journal of the American Chemical Society (2023) PDF
  1. LIGAND-TETHERED LIPID NANOPARTICLES FOR TARGETED RNA DELIVERY TO TREAT LIVER FIBROSIS
    X. Han, N. Gong, L. Xue, M.M. Billingsley, R. El-Mayta, S.J. Shepherd, M.G. Alameh, D. Weissman, M.J. Mitchell
    Nature Communications (2023) PDF
  1. NANOPARTICLE PROTEIN CORONA: FROM STRUCTURE AND FUNCTION TO THERAPEUTIC TARGETING
    G. Bashiri, M.S. Padilla, K.L. Swingle, S.J. Shepherd, M.J. Mitchell, K. Wang
    Lab on a Chip (2023) PDF
  1. PLATELET-MIMICKING NANOSPONGES FOR FUNCTIONAL REVERSAL OF ANTIPLATELET AGENTS
    J. Xu, N. Yan, C. Wang, C. Yao, X. Han, C. Yang, J. Xu, K. Wang, M.J. Mitchell, Y. Zhang, G. Nie
    Circulation Research (2023) PDF
  1. TESTING THE IN VITRO AND IN VIVO EFFICIENCY OF mRNA-LIPID NANOPARTICLES FORMULATED BY MICROFLUIDIC MIXING
    R. El-Mayta, M.S. Padilla, M.M. Billingsley, X. Han, M.J. Mitchell
    Journal of Visualized Experiments (2023) PDF
  1. FUTURE DIRECTIONS AND RESOURCE NEEDS FOR NATIONAL HEART, LUNG, AND BLOOD INSTITUTE (NHLBI) GENE THERAPY RESEARCH: A REPORT OF AN NHLBI WORKSHOP
    C.L. McDonald, P. Qasba, D.G. Anderson, G. Bao, R.A. Colvin, D.B. Kohn, P. Malik, M.J. Mitchell, W.T. Pu, D.J. Rawlings, D.A. Williams, T.R. Flotte
    Human Gene Therapy (2023) PDF
  1. ORAL FORMULATION OF WNT INHIBITOR COMPLEX REDUCES INFLAMMATION AND FIBROSIS IN INTRAPERITONEAL IMPLANTS IN VIVO
    A.L. de Castro Santos, N.J.A. da Silva, C.T.R. Viana, L.C.C. dos Santos, G.H.C. da Silva, S.R.A. Scalzo, P.A.C. Costa, W.N. da Silva, M.T.Q. Magalhaes, I.C.G. de Jesus, A. Birbair, F. Frezard, S. Guatimosim, R.M. Haley, M.J. Mitchell, S.P. Andrade, P.P. Campos, P.P.G. Guimaraes
    Drug Delivery and Translational Research (2023) PDF
  1. DOXORUBICIN-CONJUGATED siRNA LIPID NANOPARTICLES FOR COMBINATION CANCER THERAPY
    K. Butowska, X. Han, N. Gong, R. El-Mayta, R.M. Haley, L. Xue, W. Zhong, W. Guo, K. Wang, M.J. Mitchell
    Acta Pharmaceutica Sinica B (2023) PDF

2022

  1. NANOTECHNOLOGY-BASED STRATEGIES AGAINST SARS-CoV-2 VARIANTS
    X. Huang, E. Kon, X. Han, X. Zhang, N. Kong, M.J. Mitchell, D. Peer, W. Tao
    Nature Nanotechnology (2022) PDF
  1. RATIONAL DESIGN OF BISPHOSPHONATE LIPID-LIKE MATERIALS FOR mRNA DELIVERY TO THE BONE MICROENVIRONMENT
    L. Xue, N. Gong, S.J. Shepherd, X. Xiong, X. Liao, X. Han, G. Zhao, C. Song, X. Huang, H. Zhang, M.S. Padilla, J. Qin, Y. Shi, M.G. Alameh, D.J. Pochan, K. Wang, F. Long, D. Weissman, M.J. Mitchell
    Journal of the American Chemical Society (2022) PDF
  1. LIPID NANODISCS GIVE CANCER A STING
    N. Gong, M.J. Mitchell
    Nature Materials (2022) PDF
  1. HYDROXYCHOLESTEROL SUBSTITUTION IN IONIZABLE LIPID NANOPARTICLES FOR mRNA DELIVERY TO T CELLS
    S.K. Patel, M.M. Billingsley, C. Frazee, X. Han, K.L. Swingle, J. Qin, M.G. Alameh, K. Wang, D. Weissman, M.J. Mitchell
    Journal of Controlled Release (2022) PDF
  1. ENDOTHELIAL PLASTICITY DRIVES ABERRANT VASCULARIZATION AND IMPEDES CARDIAC REPAIR AFTER MYOCARDIAL INFARCTION
    M. Huang, F. Yang, D. Zhang, M. Lin, H. Duan, R. El-Mayta, L. Zhang, L. Qin, S.V. Shewale, L. Pei, M.J. Mitchell, D.J. Rader, Y. Fan, Y. Gong
    Nature Cardiovascular Research (2022) PDF
  1. LIGHTING THE WAY TO PERSONALIZED mRNA IMMUNE CELL THERAPIES
    A.E. Metzloff, M.M. Billingsley, M.J. Mitchell
    Science Advances (2022) PDF
  1. ORTHOGONAL DESIGN OF EXPERIMENTS FOR OPTIMIZATION OF LIPID NANOPARTICLES FOR mRNA ENGINEERING OF CAR T CELLS
    M.M. Billingsley, A.G. Hamilton, D. Mai, S.K. Patel, K.L. Swingle, N.C. Sheppard, C.H. June, M.J. Mitchell
    Nano Letters (2022) PDF
  1. AMNIOTIC FLUID STABILIZED LIPID NANOPARTICLES FOR IN UTERO INTRA-AMNIOTIC mRNA DELIVERY
    K.L. Swingle, M.M. Billingsley, S.K. Bose, B. White, R. Palanki, A. Dave, S.K. Patel, N. Gong, A.G. Hamilton, M.G. Alameh, D. Weissman, W.H. Peranteau, M.J. Mitchell
    Journal of Controlled Release (2022) PDF
  1. RGD PEPTIDE-BASED LIPIDS FOR TARGETED mRNA DELIVERY AND GENE EDITING APPLICATIONS
    J. Qin, L. Xue, N. Gong, H. Zhang, S.J. Shepherd, R.M. Haley, K.L. Swingle, M.J. Mitchell
    RSC Advances (2022) PDF
  1. CYTOSOLIC DELIVERY OF SMALL PROTEIN SCAFFOLDS ENABLES EFFICIENT INHIBITION OF RAS AND MYC
    A. Chan, H.H. Wang, R.M. Haley, C. Song, D. Gonzalez-Martinez, L. Bugaj, M.J. Mitchell, A. Tsourkas
    Molecular Pharmaceutics (2022) PDF
  1. RATIONAL DESIGN OF ANTI-INFLAMMATORY LIPID NANOPARTICLES FOR mRNA DELIVERY
    H. Zhang, X. Han, M.G. Alameh, S.J. Shepherd, M.S. Padilla, L. Xue, K. Butowska, D. Weissman, M.J. Mitchell
    Journal of Biomedical Materials Research Part A (2022) PDF
  1. A (CONTROLLED) SPILL OF IL-2 OF LOCALIZED TREATMENT OF MESOTHELIOMA
    R. Palanki, K.L. Swingle, M.J. Mitchell
    Clinical Cancer Research (2022) PDF
  1. DRUG DELIVERY TECHNOLOGIES FOR FETAL, NEONATAL, AND MATERNAL THERAPY
    R. Palanki, W.H. Peranteau, M.J. Mitchell
    Advanced Drug Delivery Reviews (2022) PDF
  1. IONIZABLE LIPID NANOPARTICLE-MEDIATED DELIVERY OF PLASMID DNA IN CARDIOMYOCYTES
    S. Scalzo, H.A.S. Ferreira, P.A. Costa, P.H.D.M. Prazeres, N.J.A. da Silva, L.C. Guimaraes, M.D.M. e Silva, M.T.R. Rodrigues Alves, C.T.R. Viana, I.C.G. Jesus, A.P. Rodrigues, A. Birbrair, A.O. Lobo, F. Frezard, M.J. Mitchell, S. Guatimosim, P.P.G. Guimaraes
    International Journal of Nanomedicine (2022) PDF
  1. ADDED TO PRE-EXISTING INFLAMMATION, mRNA-LIPID NANOPARTICLES INDUCE INFLAMMATION EXACERBATION (IE)
    H. Parhiz, J.S. Brenner, P. Patel, T.E. Papp, H. Shahnawaz, Q. Li, R. Shi, M. Zamora, A. Yadegari, O.A. Marcos-Contreras, A. Natesan, N. Pardi, V. Shuvaev, R. Kiseleva, J. Myerson, T. Uhler, R.S. Riley, X. Han, M.J. Mitchell, K. Lam, J. Heyes, D. Weissman, V. Muzykantov
    Journal of Controlled Release (2022) PDF

2021

  1. AN IONIZABLE LIPID TOOLBOX FOR RNA DELIVERY
    X. Han, H. Zhang, K. Butowska, K.L. Swingle, M.G. Alameh, D. Weissman, M.J. Mitchell
    Nature Communications (2021) PDF
  1. SCALABLE mRNA AND siRNA LIPID NANOPARTICLE PRODUCTION USING A PARALLELIZED MICROFLUIDIC DEVICE
    S.J. Shepherd, C.C. Warzecha, S. Yadavali, R. El-Mayta, M.G. Alameh, L. Wang, D. Weissman, J.M. Wilson, D. Issadore, M.J. Mitchell
    Nano Letters (2021) PDF
  1. IONIZABLE LIPID NANOPARTICLES FOR IN UTERO mRNA DELIVERY
    R.S. Riley, M.V. Kashyap, M.M. Billingsley, B. White, M.G. Alameh, S.K. Bose, P.W. Zoltick, H. Li, R. Zhang, A.Y. Cheng, D. Weissman, W.H. Peranteau, M.J. Mitchell
    Science Advances (2021) PDF
  1. NANOMATERIALS FOR T-CELL CANCER IMMUNOTHERAPY
    N. Gong, N.C. Sheppard, M.M. Billingsley, C.H. June, M.J. Mitchell
    Nature Nanotechnology (2021) PDF
  1. ENGINEERING PRECISION NANOPARTICLES FOR DRUG DELIVERY
    M.J. Mitchell, M.M. Billingsley, R.M. Haley, M.E. Wechsler, N.A. Peppas, R. Langer
    Nature Reviews Drug Discovery (2021) PDF
  1. ONE-COMPONENT MULTIFUNCTIONAL SEQUENCE-DEFINED IONIZABLE AMPHIPHILIC JANUS DENDRIMER DELIVERY SYSTEMS FOR mRNA
    D. Zhang, E.N. Atochina-Vasserman, D.S. Maurya, N. Huang, Q. Xiao, N. Orna, M. Liu, H. Shahnawaz, H. Ni, K. Kim, M.M. Billingsley, D.J. Pochan, M.J. Mitchell, D. Weissman, V. Percec
    Journal of the American Chemical Society (2021) PDF
  1. MICROFLUIDIC FORMULATION OF NANOPARTICLES FOR BIOMEDICAL APPLICATIONS
    S.J. Shepherd, D. Issadore, M.J. Mitchell
    Biomaterials (2021) PDF
  1. LIPID NANOPARTICLE-MEDIATED DELIVERY OF mRNA THERAPEUTICS AND VACCINES
    K.L. Swingle, A.G. Hamilton, M.J. Mitchell
    Trends in Molecular Medicine (2021) PDF
  1. HELPER LIPID STRUCTURE INFLUENCES PROTEIN ADSORPTION AND DELIVERY OF LIPID NANOPARTICLES TO SPLEEN AND LIVER
    R. Zhang, R. El-Mayta, T.J. Murdoch, C.C. Warzecha, M.M. Billingsley, S.J. Shepherd, N. Gong, L. Wang, J.M. Wilson, D. Lee, M.J. Mitchell
    Biomaterials Science (2021) PDF
  1. A NANOPARTICLE PLATFORM FOR ACCELERATED ORAL DELIVERY SCREENING OF NUCLEIC ACIDS
    R. El-Mayta, R. Zhang, S.J. Shepherd, F. Wang, M.M. Billingsley, V. Dudkin, D. Klein, H.D. Lu, M.J. Mitchell
    Advanced Therapeutics (2021) PDF
  1. DELIVERY TECHNOLOGIES FOR T CELL GENE EDITING: APPLICATIONS IN CANCER IMMUNOTHERAPY
    E. Atsavapranee, M.M. Billingsley, M.J. Mitchell
    EBioMedicine (2021) PDF
  1. DELIVERY TECHNOLOGIES TO ENGINEER NATURAL KILLER CELLS FOR CANCER IMMUNOTHERAPY
    R. El-Mayta, Z. Zhang, A.G. Hamilton, M.J. Mitchell
    Cancer Gene Therapy (2021) PDF
  1. PEPTIDE FUNCTIONALIZED LIPOSOMES FOR RECEPTOR TARGETED CANCER THERAPY
    M.R. Aronson, S.H. Medina, M.J. Mitchell
    APL Bioengineering (2021) PDF
  1. DELIVERY TECHNOLOGIES FOR IN UTERO GENE THERAPY
    R. Palanki, W.H. Peranteau, M.J. Mitchell
    Advanced Drug Delivery Reviews (2021) PDF
  1. SUMMARY FROM THE FIRST KIDNEY CANCER RESEARCH SUMMIT, SEPTEMBER 12-13, 2019: A FOCUS ON TRANSLATIONAL RESEARCH
    T.K. Choueiri, M.B. Atkins, Z. Bakouny, M.I. Carlo, C.G. Drake, E. Jonasch, P. Kapur, B. Lewis, W.M. Linehan, M.J. Mitchell, S.K. Pal, K. Pels, S. Poteat, W.K. Rathmell, B.I. Rini, S. Signoretti, N. Tannir, R. Uzzo, C.G. Wood, H.J. Hammers
    Journal of the National Cancer Institute (2021) PDF

2020

  1. IONIZABLE LIPID NANOPARTICLE MEDIATED mRNA DELIVERY FOR HUMAN CAR T CELL ENGINEERING
    M.M. Billingsley, N. Singh, P. Ravikumar, R. Zhang, C.H. June, M.J. Mitchell
    Nano Letters (2020) PDF
  1. PROTON-DRIVEN TRANSFORMABLE NANOVACCINE FOR CANCER IMMUNOTHERAPY
    N. Gong, Y. Zhang, X. Teng, Y. Wang, S. Huo, G. Qing, Q. Ni, X. Li, J. Wang, X. Ye, T. Zhang, S. Chen, Y. Wang, J. Yu, P.C. Wang, Y. Gan, J. Zhang, M.J. Mitchell, J. Li, X.J. Liang
    Nature Nanotechnology (2020) PDF
  1. NANOPARTICLE-ENCAPSULATED siRNAs FOR GENE SILENCING IN THE HAEMATOPOIETIC STEM-CELL NICHE
    M. Krohn-Grimberghe, M.J. Mitchell, M.J. Schloss, O.F. Khan, G. Courties, P.P.G. Guimaraes, D. Rohde, S. Cremer, P.S. Kowalski, Y. Sun, M. Tan, J. Webster, K. Wang, Y. Iwamoto, S.P. Schmidt, G.R. Wojtkiewicz, R. Nayar, V. Frodermann, M. Hulsmans, A. Chung, F.F. Hoyer, F.K. Swirski, R. Langer, D.G. Anderson, M. Nahrendorf
    Nature Biomedical Engineering (2020) PDF
  1. CYCLODEXTRINS IN DRUG DELIVERY: APPLICATIONS IN GENE AND COMBINATION THERAPY
    R.M. Haley, R. Gottardi, R. Langer, M.J. Mitchell
    Drug Delivery and Translational Research (2020) PDF
  1. NANOMATERIALS FOR THERAPEUTIC RNA DELIVERY
    X. Han, M.J. Mitchell, G. Nie
    Matter (2020) PDF
  1. EXPLOITING THE PLACENTA FOR NANOPARTICLE-MEDIATED DRUG DELIVERY DURING PREGNANCY
    C.G. Figueroa-Espada, S. Hofbauer, M.J. Mitchell, R.S. Riley
    Advanced Drug Delivery Reviews (2020) PDF
  1. CHIRAL SUPRAPARTICLES FOR CONTROLLABLE NANOMEDICINE
    J. Yeom, P.P.G. Guimarães, H.M. Ahn, B.K. Jung, Q. Hu, K. McHugh, M.J. Mitchell, C.O. Yun, R. Langer, A. Jaklenec
    Advanced Materials (2020) PDF

2019

  1. IONIZABLE LIPID NANOPARTICLES ENCAPSULATING BARCODED mRNA FOR ACCELERATED IN VIVO DELIVERY SCREENING 
    P.P.G. Guimarães, R. Zhang, R. Spektor, M. Tan, A. Chung, M.M. Billingsley, R. El-Mayta, R.S. Riley, L. Wang, J.M. Wilson, M.J. Mitchell
    Journal of Controlled Release (2019) PDF
  1. DELIVERY TECHNOLOGIES FOR CANCER IMMUNOTHERAPY
    R.S. Riley, C.H. June, R. Langer, M.J. Mitchell
    Nature Reviews Drug Discovery (2019) PDF
  1. NANOPARTICLES FOR NUCLEIC ACID DELIVERY: APPLICATIONS IN CANCER IMMUNOTHERAPY
    A.J. Mukalel, R.S. Riley, R. Zhang, M.J. Mitchell
    Cancer Letters (2019) PDF

2018

  1. POTENT IN VIVO LUNG CANCER WNT SIGNALING INHIBITION VIA CYCLODEXTRIN-LGK974 INCLUSION COMPLEXES
    P.P.G. Guimarães, M. Tan, T. Tammela, K. Wu, A. Chung, M. Oberli, K. Wang, R. Spektor, R.S. Riley, C. Viana, T. Jacks, R. Langer, M.J. Mitchell
    Journal of Controlled Release (2018) PDF
  1. BIOMATERIALS FOR VACCINE-BASED CANCER IMMUNOTHERAPY
    R. Zhang, M.M. Billingsley, M.J. Mitchell
    Journal of Controlled Release (2018) PDF
  1. NANOPARTICLES FOR IMMUNE CYTOKINE TRAIL-BASED CANCER THERAPY
    P.P.G. Guimarães, S. Gaglione, T. Sewastianik, R. Carrasco, R. Langer, M.J. Mitchell
    ACS Nano (2018) PDF
  1. NANOMATERIAL INTERACTIONS WITH HUMAN NEUTROPHILS
    P.W. Bisso, S. Gaglione, P.P.G. Guimaraes, M.J. Mitchell, R. Langer
    ACS Biomaterials Science & Engineering (2018) PDF
  1. ADVANCES IN BIOMATERIALS FOR DRUG DELIVERY
    O.S. Fenton, K.N. Olafson, P.S. Pillai, M.J. Mitchell, R. Langer
    Advanced Materials (2018) PDF

2017

  1. ENGINEERING AND PHYSICAL SCIENCES IN ONCOLOGY: CHALLENGES AND OPPORTUNITIES
    M.J. Mitchell, R.K. Jain, R. Langer
    Nature Reviews Cancer (2017) PDF
  1. POLYMERIC MECHANICAL AMPLIFIERS OF IMMUNE CYTOKINE-MEDIATED APOPTOSIS
    M.J. Mitchell, J. Webster, A. Chung, P.P.G. Guimarães, O.F. Khan, R. Langer
    Nature Communications (2017) PDF
  1. NANOSTRUCTURED FIBROUS MEMBRANES WITH ROSE SPIKE-LIKE ARCHITECTURE
    A. Nasajpour, S. Mandla, S. Shree, E. Mostafavi, S. Sharifi, A. Khalilpour, S. Saghazadeh, S. Hassan, M.J. Mitchell, J. Leijten, A. Moshaverinia, X. Hou, N. Annabi, R. Adelung, Y.K. Mishra, S.R. Shin, A. Tamayol, A. Khademhosseini
    Nano Letters (2017) PDF
  1. LIPID NANOPARTICLE–ASSISTED mRNA DELIVERY FOR POTENT CANCER IMMUNOTHERAPY
    M.A. Oberli, A.M. Reichmuth, J.R. Dorkin, M.J. Mitchell, O. Fenton, A. Jaklenec, D.G. Anderson, R. Langer, D. Blankschtein
    Nano Letters (2017) PDF

2016

  1. TRAIL-COATED LEUKOCYTES THAT PREVENT THE BLOODBORNE METASTASIS OF PROSTATE CANCER
    E.C. Wayne, S. Chandrasekaran, M.J. Mitchell, M.F. Chan, R.E. Lee, C.B. Schaffer, M.R. King
    Journal of Controlled Release (2016) PDF

2015

  1. LAMIN A/C DEFICIENCY REDUCES CIRCULATING TUMOR CELL RESISTANCE TO FLUID SHEAR STRESS
    M.J. Mitchell, C. Denais, M.F. Chan, X. Wang, J. Lammerding, M.R. King
    American Journal of Physiology – Cell Physiology (2015) PDF
  1. IMMOBILIZED SURFACTANT-NANOTUBE COMPLEXES SUPPORT SELECTIN-MEDIATED CAPTURE OF VIABLE CIRCULATING TUMOR CELLS IN THE ABSENCE OF CAPTURE ANTIBODIES
    M.J. Mitchell, C.A. Castellanos, M.R. King
    Journal of Biomedical Materials Research Part A (2015) PDF
  1. LEUKOCYTES AS CARRIERS FOR TARGETED CANCER DRUG DELIVERY
    M.J. Mitchell, M.R. King
    Expert Opinion on Drug Delivery (2015) PDF
  1. COOPERATIVE EFFECTS OF SUBSTRATE STIFFNESS AND FLUID SHEAR STRESS ON ENDOTHELIAL CELL BEHAVIOR
    J.C. Kohn, D.W. Zhou, F. Bordeleau, A. Zhou, B.N. Mason, M.J. Mitchell, M.R. King, C.A. Reinhart-King
    Biophysical Journal (2015) PDF

2014

  1. TRAIL-COATED LEUKOCYTES THAT KILL CANCER CELLS IN CIRCULATION
    M.J. Mitchell, E. Wayne, K. Rana, C.B. Schaffer, M.R. King
    PNAS (2014) PDF
  1. UNNATURAL KILLER CELLS TO PREVENT BLOODBORNE METASTASIS: INSPIRATION FROM BIOLOGY AND ENGINEERING
    M.J. Mitchell, M.R. King
    Expert Review of Anticancer Therapy (2014) PDF
  1. FLUID SHEAR STRESS INCREASES NEUTROPHIL ACTIVATION VIA PLATELET-ACTIVATING FACTOR
    M.J. Mitchell, K.S. Lin, M.R. King
    Biophysical Journal (2014) PDF
  1. THE ROLE OF CELL GLYCOCALYX IN VASCULAR TRANSPORT OF CIRCULATING TUMOR CELLS
    M.J. Mitchell, M.R. King
    American Journal of Physiology - Cell Physiology (2014) PDF
  1. A MICROFLUIDIC DEVICE TO SORT CELLS BASED ON CHEMOTACTIC PHENOTYPE
    S. Bajpai, M.J. Mitchell, M.R. King, C.A. Reinhart-King
    Technology (2014) PDF

2013

  1. STEM CELL ENRICHMENT VIA SELECTIN RECEPTORS: MIMICKING THE PH ENVIRONMENT OF TRAUMA
    T.M. Cao, M.J. Mitchell, J. Liesveld, M.R. King
    Sensors (2013) PDF

2012

  1. NANOSTRUCTURED SURFACES TO TARGET AND KILL CIRCULATING TUMOR CELLS WHILE REPELLING LEUKOCYTES
    M.J. Mitchell, C.A. Castellanos, M.R. King
    Journal of Nanomaterials (2012) PDF
  1. E-SELECTIN LIPOSOMAL AND NANOTUBE-TARGETED DELIVERY OF DOXORUBICIN TO CIRCULATING TUMOR CELLS
    M.J. Mitchell, C.S. Chen, V. Ponmudi, A.D. Hughes, M.R. King
    Journal of Controlled Release (2012) PDF