2022
- RGD PEPTIDE-BASED LIPIDS FOR TARGETED mRNA DELIVERY AND GENE EDITING APPLICATIONS
J. Qin, L. Xue, N. Gong, H. Zhang, S.J. Shepherd, R.M. Haley, K.L. Swingle, M.J. Mitchell
RSC Advances (2022) PDF
- DRUG DELIVERY TECHNOLOGIES FOR FETAL, NEONATAL, AND MATERNAL THERAPY
R. Palanki, W.H. Peranteau, M.J. Mitchell
Advanced Drug Delivery Reviews (2022) PDF
- NANOTECHNOLOGY-BASED STRATEGIES AGAINST SARS-CoV-2 VARIANTS
X. Huang, E. Kon, X. Han, X. Zhang, N. Kong, M.J. Mitchell, D. Peer, W. Tao
Nature Nanotechnology (2022) PDF
- RATIONAL DESIGN OF BISPHOSPHONATE LIPID-LIKE MATERIALS FOR mRNA DELIVERY TO THE BONE MICROENVIRONMENT
L. Xue, N. Gong, S.J. Shepherd, X. Xiong, X. Liao, X. Han, G. Zhao, C. Song, X. Huang, H. Zhang, M.S. Padilla, J. Qin, Y. Shi, M.G. Alameh, D.J. Pochan, K. Wang, F. Long, D. Weissman, M.J. Mitchell
Journal of the American Chemical Society (2022) PDF
- LIPID NANODISCS GIVE CANCER A STING
N. Gong, M.J. Mitchell
Nature Materials (2022) PDF
- DOXORUBICIN-CONJUGATED siRNA LIPID NANOPARTICLES FOR COMBINATION CANCER THERAPY
K. Butowska, X. Han, N. Gong, R. El-Mayta, R.M. Haley, L. Xue, W. Zhong, W. Guo K. Wang, M.J. Mitchell
Acta Pharmaceutica Sinica B (2022) PDF
- IONIZABLE LIPID NANOPARTICLE-MEDIATED DELIVERY OF PLASMID DNA IN CARDIOMYOCYTES
S. Scalzo, H.A.S. Ferreira, P.A. Costa, P.H.D.M. Prazeres, N.J.A. da Silva, L.C. Guimaraes, M.D.M. e Silva, M.T.R. Rodrigues Alves, C.T.R. Viana, I.C.G. Jesus, A.P. Rodrigues, A. Birbrair, A.O. Lobo, F. Frezard, M.J. Mitchell, S. Guatimosim, P.P.G. Guimaraes
International Journal of Nanomedicine (2022) PDF
- HYDROXYCHOLESTEROL SUBSTITUTION IN IONIZABLE LIPID NANOPARTICLES FOR mRNA DELIVERY TO T CELLS
S.K. Patel, M.M. Billingsley, C. Frazee, X. Han, K.L. Swingle, J. Qin, M.G. Alameh, K. Wang, D. Weissman, M.J. Mitchell
Journal of Controlled Release (2022) PDF
- ENDOTHELIAL PLASTICITY DRIVES ABERRANT VASCULARIZATION AND IMPEDES CARDIAC REPAIR AFTER MYOCARDIAL INFARCTION
M. Huang, F. Yang, D. Zhang, M. Lin, H. Duan, R. El-Mayta, L. Zhang, L. Qin, S.V. Shewale, L. Pei, M.J. Mitchell, D.J. Rader, Y. Fan, Y. Gong
Nature Cardiovascular Research (2022) PDF
- CYTOSOLIC DELIVERY OF SMALL PROTEIN SCAFFOLDS ENABLES EFFICIENT INHIBITION OF RAS AND MYC
A. Chan, H.H. Wang, R.M. Haley, C. Song, D. Gonzalez-Martinez, L. Bugaj, M.J. Mitchell, A. Tsourkas
Molecular Pharmaceutics (2022) PDF
- LIGHTING THE WAY TO PERSONALIZED mRNA IMMUNE CELL THERAPIES
A.E. Metzloff, M.M. Billingsley, M.J. Mitchell
Science Advances (2022) PDF
- RATIONAL DESIGN OF ANTI-INFLAMMATORY LIPID NANOPARTICLES FOR mRNA DELIVERY
H. Zhang, X. Han, M.G. Alameh, S.J. Shepherd, M.S. Padilla, L. Xue, K. Butowska, D. Weissman, M.J. Mitchell
Journal of Biomedical Materials Research Part A (2022) PDF
- ADDED TO PRE-EXISTING INFLAMMATION, mRNA-LIPID NANOPARTICLES INDUCE INFLAMMATION EXACERBATION (IE)
H. Parhiz, J.S. Brenner, P. Patel, T.E. Papp, H. Shahnawaz, Q. Li, R. Shi, M. Zamora, A. Yadegari, O.A. Marcos-Contreras, A. Natesan, N. Pardi, V. Shuvaev, R. Kiseleva, J. Myerson, T. Uhler, R.S. Riley, X. Han, M.J. Mitchell, K. Lam, J. Heyes, D. Weissman, V. Muzykantov
Journal of Controlled Release (2022) PDF
- ORTHOGONAL DESIGN OF EXPERIMENTS FOR OPTIMIZATION OF LIPID NANOPARTICLES FOR mRNA ENGINEERING OF CAR T CELLS
M.M. Billingsley, A.G. Hamilton, D. Mai, S.K. Patel, K.L. Swingle, N.C. Sheppard, C.H. June, M.J. Mitchell
Nano Letters (2022) PDF
- AMNIOTIC FLUID STABILIZED LIPID NANOPARTICLES FOR IN UTERO INTRA-AMNIOTIC mRNA DELIVERY
K.L. Swingle, M.M. Billingsley, S.K. Bose, B. White, R. Palanki, A. Dave, S.K. Patel, N. Gong, A.G. Hamilton, M.G. Alameh, D. Weissman, W.H. Peranteau, M.J. Mitchell
Journal of Controlled Release (2022) PDF
2021
- AN IONIZABLE LIPID TOOLBOX FOR RNA DELIVERY
X. Han, H. Zhang, K. Butowska, K.L. Swingle, M.G. Alameh, D. Weissman, M.J. Mitchell
Nature Communications (2021) PDF
- SCALABLE mRNA AND siRNA LIPID NANOPARTICLE PRODUCTION USING A PARALLELIZED MICROFLUIDIC DEVICE
S.J. Shepherd, C.C. Warzecha, S. Yadavali, R. El-Mayta, M.G. Alameh, L. Wang, D. Weissman, J.M. Wilson, D. Issadore, M.J. Mitchell
Nano Letters (2021) PDF
- ONE-COMPONENT MULTIFUNCTIONAL SEQUENCE-DEFINED IONIZABLE AMPHIPHILIC JANUS DENDRIMER DELIVERY SYSTEMS FOR mRNA
D. Zhang, E.N. Atochina-Vasserman, D.S. Maurya, N. Huang, Q. Xiao, N. Orna, M. Liu, H. Shahnawaz, H. Ni, K. Kim, M.M. Billingsley, D.J. Pochan, M.J. Mitchell, D. Weissman, V. Percec
Journal of the American Chemical Society (2021) PDF
- MICROFLUIDIC FORMULATION OF NANOPARTICLES FOR BIOMEDICAL APPLICATIONS
S.J. Shepherd, D. Issadore, M.J. Mitchell
Biomaterials (2021) PDF
- LIPID NANOPARTICLE-MEDIATED DELIVERY OF mRNA THERAPEUTICS AND VACCINES
K.L. Swingle, A.G. Hamilton, M.J. Mitchell
Trends in Molecular Medicine (2021) PDF
- IONIZABLE LIPID NANOPARTICLES FOR IN UTERO mRNA DELIVERY
R.S. Riley, M.V. Kashyap, M.M. Billingsley, B. White, M.G. Alameh, S.K. Bose, P.W. Zoltick, H. Li, R. Zhang, A.Y. Cheng, D. Weissman, W.H. Peranteau, M.J. Mitchell
Science Advances (2021) PDF
- NANOMATERIALS FOR T-CELL CANCER IMMUNOTHERAPY
N. Gong, N.C. Sheppard, M.M. Billingsley, C.H. June, M.J. Mitchell
Nature Nanotechnology (2021) PDF
- ENGINEERING PRECISION NANOPARTICLES FOR DRUG DELIVERY
M.J. Mitchell, M.M. Billingsley, R.M. Haley, M.E. Wechsler, N.A. Peppas, R. Langer
Nature Reviews Drug Discovery (2021) PDF
- HELPER LIPID STRUCTURE INFLUENCES PROTEIN ADSORPTION AND DELIVERY OF LIPID NANOPARTICLES TO SPLEEN AND LIVER
R. Zhang, R. El-Mayta, T.J. Murdoch, C.C. Warzecha, M.M. Billingsley, S.J. Shepherd, N. Gong, L. Wang, J.M. Wilson, D. Lee, M.J. Mitchell
Biomaterials Science (2021) PDF
- A NANOPARTICLE PLATFORM FOR ACCELERATED ORAL DELIVERY SCREENING OF NUCLEIC ACIDS
R. El-Mayta, R. Zhang, S.J. Shepherd, F. Wang, M.M. Billingsley, V. Dudkin, D. Klein, H.D. Lu, M.J. Mitchell
Advanced Therapeutics (2021) PDF
- DELIVERY TECHNOLOGIES FOR T CELL GENE EDITING: APPLICATIONS IN CANCER IMMUNOTHERAPY
E. Atsavapranee, M.M. Billingsley, M.J. Mitchell
EBioMedicine (2021) PDF
- DELIVERY TECHNOLOGIES TO ENGINEER NATURAL KILLER CELLS FOR CANCER IMMUNOTHERAPY
R. El-Mayta, Z. Zhang, A.G. Hamilton, M.J. Mitchell
Cancer Gene Therapy (2021) PDF
- PEPTIDE FUNCTIONALIZED LIPOSOMES FOR RECEPTOR TARGETED CANCER THERAPY
M.R. Aronson, S.H. Medina, M.J. Mitchell
APL Bioengineering (2021) PDF
- DELIVERY TECHNOLOGIES FOR IN UTERO GENE THERAPY
R. Palanki, W.H. Peranteau, M.J. Mitchell
Advanced Drug Delivery Reviews (2021) PDF
- SUMMARY FROM THE FIRST KIDNEY CANCER RESEARCH SUMMIT, SEPTEMBER 12-13, 2019: A FOCUS ON TRANSLATIONAL RESEARCH
T.K. Choueiri, M.B. Atkins, Z. Bakouny, M.I. Carlo, C.G. Drake, E. Jonasch, P. Kapur, B. Lewis, W.M. Linehan, M.J. Mitchell, S.K. Pal, K. Pels, S. Poteat, W.K. Rathmell, B.I. Rini, S. Signoretti, N. Tannir, R. Uzzo, C.G. Wood, H.J. Hammers
Journal of the National Cancer Institute (2021) PDF
2020
- IONIZABLE LIPID NANOPARTICLE MEDIATED mRNA DELIVERY FOR HUMAN CAR T CELL ENGINEERING
M.M. Billingsley, N. Singh, P. Ravikumar, R. Zhang, C.H. June, M.J. Mitchell
Nano Letters (2020) PDF
- PROTON-DRIVEN TRANSFORMABLE NANOVACCINE FOR CANCER IMMUNOTHERAPY
N. Gong, Y. Zhang, X. Teng, Y. Wang, S. Huo, G. Qing, Q. Ni, X. Li, J. Wang, X. Ye, T. Zhang, S. Chen, Y. Wang, J. Yu, P.C. Wang, Y. Gan, J. Zhang, M.J. Mitchell, J. Li, X.J. Liang
Nature Nanotechnology (2020) PDF
- NANOPARTICLE-ENCAPSULATED siRNAs FOR GENE SILENCING IN THE HAEMATOPOIETIC STEM-CELL NICHE
M. Krohn-Grimberghe, M.J. Mitchell, M.J. Schloss, O.F. Khan, G. Courties, P.P.G. Guimaraes, D. Rohde, S. Cremer, P.S. Kowalski, Y. Sun, M. Tan, J. Webster, K. Wang, Y. Iwamoto, S.P. Schmidt, G.R. Wojtkiewicz, R. Nayar, V. Frodermann, M. Hulsmans, A. Chung, F.F. Hoyer, F.K. Swirski, R. Langer, D.G. Anderson, M. Nahrendorf
Nature Biomedical Engineering (2020) PDF
- CYCLODEXTRINS IN DRUG DELIVERY: APPLICATIONS IN GENE AND COMBINATION THERAPY
R.M. Haley, R. Gottardi, R. Langer, M.J. Mitchell
Drug Delivery and Translational Research (2020) PDF
- NANOMATERIALS FOR THERAPEUTIC RNA DELIVERY
X. Han, M.J. Mitchell, G. Nie
Matter (2020) PDF
- EXPLOITING THE PLACENTA FOR NANOPARTICLE-MEDIATED DRUG DELIVERY DURING PREGNANCY
C.G. Figueroa-Espada, S. Hofbauer, M.J. Mitchell, R.S. Riley
Advanced Drug Delivery Reviews (2020) PDF
- CHIRAL SUPRAPARTICLES FOR CONTROLLABLE NANOMEDICINE
J. Yeom, P.P.G. Guimarães, H.M. Ahn, B.K. Jung, Q. Hu, K. McHugh, M.J. Mitchell, C.O. Yun, R. Langer, A. Jaklenec
Advanced Materials (2020) PDF
2019
- IONIZABLE LIPID NANOPARTICLES ENCAPSULATING BARCODED mRNA FOR ACCELERATED IN VIVO DELIVERY SCREENING
P.P.G. Guimarães, R. Zhang, R. Spektor, M. Tan, A. Chung, M.M. Billingsley, R. El-Mayta, R.S. Riley, L. Wang, J.M. Wilson, M.J. Mitchell
Journal of Controlled Release (2019) PDF
- DELIVERY TECHNOLOGIES FOR CANCER IMMUNOTHERAPY
R.S. Riley, C.H. June, R. Langer, M.J. Mitchell
Nature Reviews Drug Discovery (2019) PDF
- NANOPARTICLES FOR NUCLEIC ACID DELIVERY: APPLICATIONS IN CANCER IMMUNOTHERAPY
A.J. Mukalel, R.S. Riley, R. Zhang, M.J. Mitchell
Cancer Letters (2019) PDF
2018
- POTENT IN VIVO LUNG CANCER WNT SIGNALING INHIBITION VIA CYCLODEXTRIN-LGK974 INCLUSION COMPLEXES
P.P.G. Guimarães, M. Tan, T. Tammela, K. Wu, A. Chung, M. Oberli, K. Wang, R. Spektor, R.S. Riley, C. Viana, T. Jacks, R. Langer, M.J. Mitchell
Journal of Controlled Release (2018) PDF
- BIOMATERIALS FOR VACCINE-BASED CANCER IMMUNOTHERAPY
R. Zhang, M.M. Billingsley, M.J. Mitchell
Journal of Controlled Release (2018) PDF
- NANOPARTICLES FOR IMMUNE CYTOKINE TRAIL-BASED CANCER THERAPY
P.P.G. Guimarães, S. Gaglione, T. Sewastianik, R. Carrasco, R. Langer, M.J. Mitchell
ACS Nano (2018) PDF
- NANOMATERIAL INTERACTIONS WITH HUMAN NEUTROPHILS
P.W. Bisso, S. Gaglione, P.P.G. Guimaraes, M.J. Mitchell, R. Langer
ACS Biomaterials Science & Engineering (2018) PDF
- ADVANCES IN BIOMATERIALS FOR DRUG DELIVERY
O.S. Fenton, K.N. Olafson, P.S. Pillai, M.J. Mitchell, R. Langer
Advanced Materials (2018) PDF
2017
- ENGINEERING AND PHYSICAL SCIENCES IN ONCOLOGY: CHALLENGES AND OPPORTUNITIES
M.J. Mitchell, R.K. Jain, R. Langer
Nature Reviews Cancer (2017) PDF
- POLYMERIC MECHANICAL AMPLIFIERS OF IMMUNE CYTOKINE-MEDIATED APOPTOSIS
M.J. Mitchell, J. Webster, A. Chung, P.P.G. Guimarães, O.F. Khan, R. Langer
Nature Communications (2017) PDF
- NANOSTRUCTURED FIBROUS MEMBRANES WITH ROSE SPIKE-LIKE ARCHITECTURE
A. Nasajpour, S. Mandla, S. Shree, E. Mostafavi, S. Sharifi, A. Khalilpour, S. Saghazadeh, S. Hassan, M.J. Mitchell, J. Leijten, A. Moshaverinia, X. Hou, N. Annabi, R. Adelung, Y.K. Mishra, S.R. Shin, A. Tamayol, A. Khademhosseini
Nano Letters (2017) PDF
- LIPID NANOPARTICLE–ASSISTED mRNA DELIVERY FOR POTENT CANCER IMMUNOTHERAPY
M.A. Oberli, A.M. Reichmuth, J.R. Dorkin, M.J. Mitchell, O. Fenton, A. Jaklenec, D.G. Anderson, R. Langer, D. Blankschtein
Nano Letters (2017) PDF
2016
- TRAIL-COATED LEUKOCYTES THAT PREVENT THE BLOODBORNE METASTASIS OF PROSTATE CANCER
E.C. Wayne, S. Chandrasekaran, M.J. Mitchell, M.F. Chan, R.E. Lee, C.B. Schaffer, M.R. King
Journal of Controlled Release (2016) PDF
2015
- LAMIN A/C DEFICIENCY REDUCES CIRCULATING TUMOR CELL RESISTANCE TO FLUID SHEAR STRESS
M.J. Mitchell, C. Denais, M.F. Chan, X. Wang, J. Lammerding, M.R. King
American Journal of Physiology – Cell Physiology (2015) PDF
- SURFACTANT FUNCTIONALIZATION INDUCES ROBUST, DIFFERENTIAL ADHESION OF TUMOR CELLS AND BLOOD CELLS TO CHARGED NANOTUBE-COATED BIOMATERIALS UNDER FLOW
M.J. Mitchell, C.A. Castellanos, M.R. King
Biomaterials (2015) PDF
- IMMOBILIZED SURFACTANT-NANOTUBE COMPLEXES SUPPORT SELECTIN-MEDIATED CAPTURE OF VIABLE CIRCULATING TUMOR CELLS IN THE ABSENCE OF CAPTURE ANTIBODIES
M.J. Mitchell, C.A. Castellanos, M.R. King
Journal of Biomedical Materials Research Part A (2015) PDF
- LEUKOCYTES AS CARRIERS FOR TARGETED CANCER DRUG DELIVERY
M.J. Mitchell, M.R. King
Expert Opinion on Drug Delivery (2015) PDF
- COOPERATIVE EFFECTS OF SUBSTRATE STIFFNESS AND FLUID SHEAR STRESS ON ENDOTHELIAL CELL BEHAVIOR
J.C. Kohn, D.W. Zhou, F. Bordeleau, A. Zhou, B.N. Mason, M.J. Mitchell, M.R. King, C.A. Reinhart-King
Biophysical Journal (2015) PDF
2014
- TRAIL-COATED LEUKOCYTES THAT KILL CANCER CELLS IN CIRCULATION
M.J. Mitchell, E. Wayne, K. Rana, C.B. Schaffer, M.R. King
Proceedings of the National Academy of Sciences (2014) PDF
- UNNATURAL KILLER CELLS TO PREVENT BLOODBORNE METASTASIS: INSPIRATION FROM BIOLOGY AND ENGINEERING
M.J. Mitchell, M.R. King
Expert Review of Anticancer Therapy (2014) PDF
- FLUID SHEAR STRESS INCREASES NEUTROPHIL ACTIVATION VIA PLATELET-ACTIVATING FACTOR
M.J. Mitchell, K.S. Lin, M.R. King
Biophysical Journal (2014) PDF
- THE ROLE OF CELL GLYCOCALYX IN VASCULAR TRANSPORT OF CIRCULATING TUMOR CELLS
M.J. Mitchell, M.R. King
American Journal of Physiology - Cell Physiology (2014) PDF
- A MICROFLUIDIC DEVICE TO SORT CELLS BASED ON CHEMOTACTIC PHENOTYPE
S. Bajpai, M.J. Mitchell, M.R. King, C.A. Reinhart-King
Technology (2014) PDF
2013
- STEM CELL ENRICHMENT VIA SELECTIN RECEPTORS: MIMICKING THE PH ENVIRONMENT OF TRAUMA
T.M. Cao, M.J. Mitchell, J. Liesveld, M.R. King
Sensors (2013) PDF
- COMPUTATIONAL AND EXPERIMENTAL MODELS OF CANCER CELL RESPONSE TO FLUID SHEAR STRESS
M.J. Mitchell, M.R. King
Frontiers in Oncology (2013) PDF
- FLUID SHEAR STRESS SENSITIZES CANCER CELLS TO RECEPTOR-MEDIATED APOPTOSIS VIA TRIMERIC DEATH RECEPTORS
M.J. Mitchell, M.R. King
New Journal of Physics (2013) PDF
2012
- NANOSTRUCTURED SURFACES TO TARGET AND KILL CIRCULATING TUMOR CELLS WHILE REPELLING LEUKOCYTES
M.J. Mitchell, C.A. Castellanos, M.R. King
Journal of Nanomaterials (2012) PDF
- E-SELECTIN LIPOSOMAL AND NANOTUBE-TARGETED DELIVERY OF DOXORUBICIN TO CIRCULATING TUMOR CELLS
M.J. Mitchell, C.S. Chen, V. Ponmudi, A.D. Hughes, M.R. King
Journal of Controlled Release (2012) PDF
- SHEAR-INDUCED RESISTANCE TO NEUTROPHIL ACTIVATION VIA THE FORMYL PEPTIDE RECEPTOR
M.J. Mitchell, M.R. King
Biophysical Journal (2012) PDF