2023

  1. LIGAND-TETHERED LIPID NANOPARTICLES FOR TARGETED RNA DELIVERY TO TREAT LIVER FIBROSIS
    X. Han, N. Gong, L. Xue, M.M. Billingsley, R. El-Mayta, S.J. Shepherd, M.G. Alameh, D. Weissman, M.J. Mitchell
    Nature Communications (2023) PDF
  1. NANOPARTICLE PROTEIN CORONA: FROM STRUCTURE AND FUNCTION TO THERAPEUTIC TARGETING
    G. Bashiri, M.S. Padilla, K.L. Swingle, S.J. Shepherd, M.J. Mitchell, K. Wang
    Lab on a Chip (2023) PDF
  1. PLATELET-MIMICKING NANOSPONGES FOR FUNCTIONAL REVERSAL OF ANTIPLATELET AGENTS
    J. Xu, N. Yan, C. Wang, C. Yao, X. Han, C. Yang, J. Xu, K. Wang, M.J. Mitchell, Y. Zhang, G. Nie
    Circulation Research (2023) PDF
  1. TESTING THE IN VITRO AND IN VIVO EFFICIENCY OF mRNA-LIPID NANOPARTICLES FORMULATED BY MICROFLUIDIC MIXING
    R. El-Mayta, M.S. Padilla, M.M. Billingsley, X. Han, M.J. Mitchell
    Journal of Visualized Experiments (2023) PDF

2022

  1. NANOTECHNOLOGY-BASED STRATEGIES AGAINST SARS-CoV-2 VARIANTS
    X. Huang, E. Kon, X. Han, X. Zhang, N. Kong, M.J. Mitchell, D. Peer, W. Tao
    Nature Nanotechnology (2022) PDF
  1. RATIONAL DESIGN OF BISPHOSPHONATE LIPID-LIKE MATERIALS FOR mRNA DELIVERY TO THE BONE MICROENVIRONMENT
    L. Xue, N. Gong, S.J. Shepherd, X. Xiong, X. Liao, X. Han, G. Zhao, C. Song, X. Huang, H. Zhang, M.S. Padilla, J. Qin, Y. Shi, M.G. Alameh, D.J. Pochan, K. Wang, F. Long, D. Weissman, M.J. Mitchell
    Journal of the American Chemical Society (2022) PDF
  1. LIPID NANODISCS GIVE CANCER A STING
    N. Gong, M.J. Mitchell
    Nature Materials (2022) PDF
  1. HYDROXYCHOLESTEROL SUBSTITUTION IN IONIZABLE LIPID NANOPARTICLES FOR mRNA DELIVERY TO T CELLS
    S.K. Patel, M.M. Billingsley, C. Frazee, X. Han, K.L. Swingle, J. Qin, M.G. Alameh, K. Wang, D. Weissman, M.J. Mitchell
    Journal of Controlled Release (2022) PDF
  1. ENDOTHELIAL PLASTICITY DRIVES ABERRANT VASCULARIZATION AND IMPEDES CARDIAC REPAIR AFTER MYOCARDIAL INFARCTION
    M. Huang, F. Yang, D. Zhang, M. Lin, H. Duan, R. El-Mayta, L. Zhang, L. Qin, S.V. Shewale, L. Pei, M.J. Mitchell, D.J. Rader, Y. Fan, Y. Gong
    Nature Cardiovascular Research (2022) PDF
  1. LIGHTING THE WAY TO PERSONALIZED mRNA IMMUNE CELL THERAPIES
    A.E. Metzloff, M.M. Billingsley, M.J. Mitchell
    Science Advances (2022) PDF
  1. ORTHOGONAL DESIGN OF EXPERIMENTS FOR OPTIMIZATION OF LIPID NANOPARTICLES FOR mRNA ENGINEERING OF CAR T CELLS
    M.M. Billingsley, A.G. Hamilton, D. Mai, S.K. Patel, K.L. Swingle, N.C. Sheppard, C.H. June, M.J. Mitchell
    Nano Letters (2022) PDF
  1. AMNIOTIC FLUID STABILIZED LIPID NANOPARTICLES FOR IN UTERO INTRA-AMNIOTIC mRNA DELIVERY
    K.L. Swingle, M.M. Billingsley, S.K. Bose, B. White, R. Palanki, A. Dave, S.K. Patel, N. Gong, A.G. Hamilton, M.G. Alameh, D. Weissman, W.H. Peranteau, M.J. Mitchell
    Journal of Controlled Release (2022) PDF
  1. RGD PEPTIDE-BASED LIPIDS FOR TARGETED mRNA DELIVERY AND GENE EDITING APPLICATIONS
    J. Qin, L. Xue, N. Gong, H. Zhang, S.J. Shepherd, R.M. Haley, K.L. Swingle, M.J. Mitchell
    RSC Advances (2022) PDF
  1. DOXORUBICIN-CONJUGATED siRNA LIPID NANOPARTICLES FOR COMBINATION CANCER THERAPY
    K. Butowska, X. Han, N. Gong, R. El-Mayta, R.M. Haley, L. Xue, W. Zhong, W. Guo, K. Wang, M.J. Mitchell
    Acta Pharmaceutica Sinica B (2022) PDF
  1. CYTOSOLIC DELIVERY OF SMALL PROTEIN SCAFFOLDS ENABLES EFFICIENT INHIBITION OF RAS AND MYC
    A. Chan, H.H. Wang, R.M. Haley, C. Song, D. Gonzalez-Martinez, L. Bugaj, M.J. Mitchell, A. Tsourkas
    Molecular Pharmaceutics (2022) PDF
  1. RATIONAL DESIGN OF ANTI-INFLAMMATORY LIPID NANOPARTICLES FOR mRNA DELIVERY
    H. Zhang, X. Han, M.G. Alameh, S.J. Shepherd, M.S. Padilla, L. Xue, K. Butowska, D. Weissman, M.J. Mitchell
    Journal of Biomedical Materials Research Part A (2022) PDF
  1. A (CONTROLLED) SPILL OF IL-2 OF LOCALIZED TREATMENT OF MESOTHELIOMA
    R. Palanki, K.L. Swingle, M.J. Mitchell
    Clinical Cancer Research (2022) PDF
  1. DRUG DELIVERY TECHNOLOGIES FOR FETAL, NEONATAL, AND MATERNAL THERAPY
    R. Palanki, W.H. Peranteau, M.J. Mitchell
    Advanced Drug Delivery Reviews (2022) PDF
  1. IONIZABLE LIPID NANOPARTICLE-MEDIATED DELIVERY OF PLASMID DNA IN CARDIOMYOCYTES
    S. Scalzo, H.A.S. Ferreira, P.A. Costa, P.H.D.M. Prazeres, N.J.A. da Silva, L.C. Guimaraes, M.D.M. e Silva, M.T.R. Rodrigues Alves, C.T.R. Viana, I.C.G. Jesus, A.P. Rodrigues, A. Birbrair, A.O. Lobo, F. Frezard, M.J. Mitchell, S. Guatimosim, P.P.G. Guimaraes
    International Journal of Nanomedicine (2022) PDF
  1. ADDED TO PRE-EXISTING INFLAMMATION, mRNA-LIPID NANOPARTICLES INDUCE INFLAMMATION EXACERBATION (IE)
    H. Parhiz, J.S. Brenner, P. Patel, T.E. Papp, H. Shahnawaz, Q. Li, R. Shi, M. Zamora, A. Yadegari, O.A. Marcos-Contreras, A. Natesan, N. Pardi, V. Shuvaev, R. Kiseleva, J. Myerson, T. Uhler, R.S. Riley, X. Han, M.J. Mitchell, K. Lam, J. Heyes, D. Weissman, V. Muzykantov
    Journal of Controlled Release (2022) PDF

2021

  1. AN IONIZABLE LIPID TOOLBOX FOR RNA DELIVERY
    X. Han, H. Zhang, K. Butowska, K.L. Swingle, M.G. Alameh, D. Weissman, M.J. Mitchell
    Nature Communications (2021) PDF
  1. SCALABLE mRNA AND siRNA LIPID NANOPARTICLE PRODUCTION USING A PARALLELIZED MICROFLUIDIC DEVICE
    S.J. Shepherd, C.C. Warzecha, S. Yadavali, R. El-Mayta, M.G. Alameh, L. Wang, D. Weissman, J.M. Wilson, D. Issadore, M.J. Mitchell
    Nano Letters (2021) PDF
  1. IONIZABLE LIPID NANOPARTICLES FOR IN UTERO mRNA DELIVERY
    R.S. Riley, M.V. Kashyap, M.M. Billingsley, B. White, M.G. Alameh, S.K. Bose, P.W. Zoltick, H. Li, R. Zhang, A.Y. Cheng, D. Weissman, W.H. Peranteau, M.J. Mitchell
    Science Advances (2021) PDF
  1. NANOMATERIALS FOR T-CELL CANCER IMMUNOTHERAPY
    N. Gong, N.C. Sheppard, M.M. Billingsley, C.H. June, M.J. Mitchell
    Nature Nanotechnology (2021) PDF
  1. ENGINEERING PRECISION NANOPARTICLES FOR DRUG DELIVERY
    M.J. Mitchell, M.M. Billingsley, R.M. Haley, M.E. Wechsler, N.A. Peppas, R. Langer
    Nature Reviews Drug Discovery (2021) PDF
  1. ONE-COMPONENT MULTIFUNCTIONAL SEQUENCE-DEFINED IONIZABLE AMPHIPHILIC JANUS DENDRIMER DELIVERY SYSTEMS FOR mRNA
    D. Zhang, E.N. Atochina-Vasserman, D.S. Maurya, N. Huang, Q. Xiao, N. Orna, M. Liu, H. Shahnawaz, H. Ni, K. Kim, M.M. Billingsley, D.J. Pochan, M.J. Mitchell, D. Weissman, V. Percec
    Journal of the American Chemical Society (2021) PDF
  1. MICROFLUIDIC FORMULATION OF NANOPARTICLES FOR BIOMEDICAL APPLICATIONS
    S.J. Shepherd, D. Issadore, M.J. Mitchell
    Biomaterials (2021) PDF
  1. LIPID NANOPARTICLE-MEDIATED DELIVERY OF mRNA THERAPEUTICS AND VACCINES
    K.L. Swingle, A.G. Hamilton, M.J. Mitchell
    Trends in Molecular Medicine (2021) PDF
  1. HELPER LIPID STRUCTURE INFLUENCES PROTEIN ADSORPTION AND DELIVERY OF LIPID NANOPARTICLES TO SPLEEN AND LIVER
    R. Zhang, R. El-Mayta, T.J. Murdoch, C.C. Warzecha, M.M. Billingsley, S.J. Shepherd, N. Gong, L. Wang, J.M. Wilson, D. Lee, M.J. Mitchell
    Biomaterials Science (2021) PDF
  1. A NANOPARTICLE PLATFORM FOR ACCELERATED ORAL DELIVERY SCREENING OF NUCLEIC ACIDS
    R. El-Mayta, R. Zhang, S.J. Shepherd, F. Wang, M.M. Billingsley, V. Dudkin, D. Klein, H.D. Lu, M.J. Mitchell
    Advanced Therapeutics (2021) PDF
  1. DELIVERY TECHNOLOGIES FOR T CELL GENE EDITING: APPLICATIONS IN CANCER IMMUNOTHERAPY
    E. Atsavapranee, M.M. Billingsley, M.J. Mitchell
    EBioMedicine (2021) PDF
  1. DELIVERY TECHNOLOGIES TO ENGINEER NATURAL KILLER CELLS FOR CANCER IMMUNOTHERAPY
    R. El-Mayta, Z. Zhang, A.G. Hamilton, M.J. Mitchell
    Cancer Gene Therapy (2021) PDF
  1. PEPTIDE FUNCTIONALIZED LIPOSOMES FOR RECEPTOR TARGETED CANCER THERAPY
    M.R. Aronson, S.H. Medina, M.J. Mitchell
    APL Bioengineering (2021) PDF
  1. DELIVERY TECHNOLOGIES FOR IN UTERO GENE THERAPY
    R. Palanki, W.H. Peranteau, M.J. Mitchell
    Advanced Drug Delivery Reviews (2021) PDF
  1. SUMMARY FROM THE FIRST KIDNEY CANCER RESEARCH SUMMIT, SEPTEMBER 12-13, 2019: A FOCUS ON TRANSLATIONAL RESEARCH
    T.K. Choueiri, M.B. Atkins, Z. Bakouny, M.I. Carlo, C.G. Drake, E. Jonasch, P. Kapur, B. Lewis, W.M. Linehan, M.J. Mitchell, S.K. Pal, K. Pels, S. Poteat, W.K. Rathmell, B.I. Rini, S. Signoretti, N. Tannir, R. Uzzo, C.G. Wood, H.J. Hammers
    Journal of the National Cancer Institute (2021) PDF

2020

  1. IONIZABLE LIPID NANOPARTICLE MEDIATED mRNA DELIVERY FOR HUMAN CAR T CELL ENGINEERING
    M.M. Billingsley, N. Singh, P. Ravikumar, R. Zhang, C.H. June, M.J. Mitchell
    Nano Letters (2020) PDF
  1. PROTON-DRIVEN TRANSFORMABLE NANOVACCINE FOR CANCER IMMUNOTHERAPY
    N. Gong, Y. Zhang, X. Teng, Y. Wang, S. Huo, G. Qing, Q. Ni, X. Li, J. Wang, X. Ye, T. Zhang, S. Chen, Y. Wang, J. Yu, P.C. Wang, Y. Gan, J. Zhang, M.J. Mitchell, J. Li, X.J. Liang
    Nature Nanotechnology (2020) PDF
  1. NANOPARTICLE-ENCAPSULATED siRNAs FOR GENE SILENCING IN THE HAEMATOPOIETIC STEM-CELL NICHE
    M. Krohn-Grimberghe, M.J. Mitchell, M.J. Schloss, O.F. Khan, G. Courties, P.P.G. Guimaraes, D. Rohde, S. Cremer, P.S. Kowalski, Y. Sun, M. Tan, J. Webster, K. Wang, Y. Iwamoto, S.P. Schmidt, G.R. Wojtkiewicz, R. Nayar, V. Frodermann, M. Hulsmans, A. Chung, F.F. Hoyer, F.K. Swirski, R. Langer, D.G. Anderson, M. Nahrendorf
    Nature Biomedical Engineering (2020) PDF
  1. CYCLODEXTRINS IN DRUG DELIVERY: APPLICATIONS IN GENE AND COMBINATION THERAPY
    R.M. Haley, R. Gottardi, R. Langer, M.J. Mitchell
    Drug Delivery and Translational Research (2020) PDF
  1. NANOMATERIALS FOR THERAPEUTIC RNA DELIVERY
    X. Han, M.J. Mitchell, G. Nie
    Matter (2020) PDF
  1. EXPLOITING THE PLACENTA FOR NANOPARTICLE-MEDIATED DRUG DELIVERY DURING PREGNANCY
    C.G. Figueroa-Espada, S. Hofbauer, M.J. Mitchell, R.S. Riley
    Advanced Drug Delivery Reviews (2020) PDF
  1. CHIRAL SUPRAPARTICLES FOR CONTROLLABLE NANOMEDICINE
    J. Yeom, P.P.G. Guimarães, H.M. Ahn, B.K. Jung, Q. Hu, K. McHugh, M.J. Mitchell, C.O. Yun, R. Langer, A. Jaklenec
    Advanced Materials (2020) PDF

2019

  1. IONIZABLE LIPID NANOPARTICLES ENCAPSULATING BARCODED mRNA FOR ACCELERATED IN VIVO DELIVERY SCREENING 
    P.P.G. Guimarães, R. Zhang, R. Spektor, M. Tan, A. Chung, M.M. Billingsley, R. El-Mayta, R.S. Riley, L. Wang, J.M. Wilson, M.J. Mitchell
    Journal of Controlled Release (2019) PDF
  1. DELIVERY TECHNOLOGIES FOR CANCER IMMUNOTHERAPY
    R.S. Riley, C.H. June, R. Langer, M.J. Mitchell
    Nature Reviews Drug Discovery (2019) PDF
  1. NANOPARTICLES FOR NUCLEIC ACID DELIVERY: APPLICATIONS IN CANCER IMMUNOTHERAPY
    A.J. Mukalel, R.S. Riley, R. Zhang, M.J. Mitchell
    Cancer Letters (2019) PDF

2018

  1. POTENT IN VIVO LUNG CANCER WNT SIGNALING INHIBITION VIA CYCLODEXTRIN-LGK974 INCLUSION COMPLEXES
    P.P.G. Guimarães, M. Tan, T. Tammela, K. Wu, A. Chung, M. Oberli, K. Wang, R. Spektor, R.S. Riley, C. Viana, T. Jacks, R. Langer, M.J. Mitchell
    Journal of Controlled Release (2018) PDF
  1. BIOMATERIALS FOR VACCINE-BASED CANCER IMMUNOTHERAPY
    R. Zhang, M.M. Billingsley, M.J. Mitchell
    Journal of Controlled Release (2018) PDF
  1. NANOPARTICLES FOR IMMUNE CYTOKINE TRAIL-BASED CANCER THERAPY
    P.P.G. Guimarães, S. Gaglione, T. Sewastianik, R. Carrasco, R. Langer, M.J. Mitchell
    ACS Nano (2018) PDF
  1. NANOMATERIAL INTERACTIONS WITH HUMAN NEUTROPHILS
    P.W. Bisso, S. Gaglione, P.P.G. Guimaraes, M.J. Mitchell, R. Langer
    ACS Biomaterials Science & Engineering (2018) PDF
  1. ADVANCES IN BIOMATERIALS FOR DRUG DELIVERY
    O.S. Fenton, K.N. Olafson, P.S. Pillai, M.J. Mitchell, R. Langer
    Advanced Materials (2018) PDF

2017

  1. ENGINEERING AND PHYSICAL SCIENCES IN ONCOLOGY: CHALLENGES AND OPPORTUNITIES
    M.J. Mitchell, R.K. Jain, R. Langer
    Nature Reviews Cancer (2017) PDF
  1. POLYMERIC MECHANICAL AMPLIFIERS OF IMMUNE CYTOKINE-MEDIATED APOPTOSIS
    M.J. Mitchell, J. Webster, A. Chung, P.P.G. Guimarães, O.F. Khan, R. Langer
    Nature Communications (2017) PDF
  1. NANOSTRUCTURED FIBROUS MEMBRANES WITH ROSE SPIKE-LIKE ARCHITECTURE
    A. Nasajpour, S. Mandla, S. Shree, E. Mostafavi, S. Sharifi, A. Khalilpour, S. Saghazadeh, S. Hassan, M.J. Mitchell, J. Leijten, A. Moshaverinia, X. Hou, N. Annabi, R. Adelung, Y.K. Mishra, S.R. Shin, A. Tamayol, A. Khademhosseini
    Nano Letters (2017) PDF
  1. LIPID NANOPARTICLE–ASSISTED mRNA DELIVERY FOR POTENT CANCER IMMUNOTHERAPY
    M.A. Oberli, A.M. Reichmuth, J.R. Dorkin, M.J. Mitchell, O. Fenton, A. Jaklenec, D.G. Anderson, R. Langer, D. Blankschtein
    Nano Letters (2017) PDF

2016

  1. TRAIL-COATED LEUKOCYTES THAT PREVENT THE BLOODBORNE METASTASIS OF PROSTATE CANCER
    E.C. Wayne, S. Chandrasekaran, M.J. Mitchell, M.F. Chan, R.E. Lee, C.B. Schaffer, M.R. King
    Journal of Controlled Release (2016) PDF

2015

  1. LAMIN A/C DEFICIENCY REDUCES CIRCULATING TUMOR CELL RESISTANCE TO FLUID SHEAR STRESS
    M.J. Mitchell, C. Denais, M.F. Chan, X. Wang, J. Lammerding, M.R. King
    American Journal of Physiology – Cell Physiology (2015) PDF
  1. IMMOBILIZED SURFACTANT-NANOTUBE COMPLEXES SUPPORT SELECTIN-MEDIATED CAPTURE OF VIABLE CIRCULATING TUMOR CELLS IN THE ABSENCE OF CAPTURE ANTIBODIES
    M.J. Mitchell, C.A. Castellanos, M.R. King
    Journal of Biomedical Materials Research Part A (2015) PDF
  1. LEUKOCYTES AS CARRIERS FOR TARGETED CANCER DRUG DELIVERY
    M.J. Mitchell, M.R. King
    Expert Opinion on Drug Delivery (2015) PDF
  1. COOPERATIVE EFFECTS OF SUBSTRATE STIFFNESS AND FLUID SHEAR STRESS ON ENDOTHELIAL CELL BEHAVIOR
    J.C. Kohn, D.W. Zhou, F. Bordeleau, A. Zhou, B.N. Mason, M.J. Mitchell, M.R. King, C.A. Reinhart-King
    Biophysical Journal (2015) PDF

2014

  1. TRAIL-COATED LEUKOCYTES THAT KILL CANCER CELLS IN CIRCULATION
    M.J. Mitchell, E. Wayne, K. Rana, C.B. Schaffer, M.R. King
    Proceedings of the National Academy of Sciences (2014) PDF
  1. UNNATURAL KILLER CELLS TO PREVENT BLOODBORNE METASTASIS: INSPIRATION FROM BIOLOGY AND ENGINEERING
    M.J. Mitchell, M.R. King
    Expert Review of Anticancer Therapy (2014) PDF
  1. FLUID SHEAR STRESS INCREASES NEUTROPHIL ACTIVATION VIA PLATELET-ACTIVATING FACTOR
    M.J. Mitchell, K.S. Lin, M.R. King
    Biophysical Journal (2014) PDF
  1. THE ROLE OF CELL GLYCOCALYX IN VASCULAR TRANSPORT OF CIRCULATING TUMOR CELLS
    M.J. Mitchell, M.R. King
    American Journal of Physiology - Cell Physiology (2014) PDF
  1. A MICROFLUIDIC DEVICE TO SORT CELLS BASED ON CHEMOTACTIC PHENOTYPE
    S. Bajpai, M.J. Mitchell, M.R. King, C.A. Reinhart-King
    Technology (2014) PDF

2013

  1. STEM CELL ENRICHMENT VIA SELECTIN RECEPTORS: MIMICKING THE PH ENVIRONMENT OF TRAUMA
    T.M. Cao, M.J. Mitchell, J. Liesveld, M.R. King
    Sensors (2013) PDF

2012

  1. NANOSTRUCTURED SURFACES TO TARGET AND KILL CIRCULATING TUMOR CELLS WHILE REPELLING LEUKOCYTES
    M.J. Mitchell, C.A. Castellanos, M.R. King
    Journal of Nanomaterials (2012) PDF
  1. E-SELECTIN LIPOSOMAL AND NANOTUBE-TARGETED DELIVERY OF DOXORUBICIN TO CIRCULATING TUMOR CELLS
    M.J. Mitchell, C.S. Chen, V. Ponmudi, A.D. Hughes, M.R. King
    Journal of Controlled Release (2012) PDF